The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Macrophages are crucial members of the innate immune response and important regulators.
The differentiation and activation of macrophages require the timely regulation of gene …

Cells primarily rely on proteins to perform the majority of their physiological functions, and
the function of proteins is regulated by post‑translational modifications (PTMs). The …

Overcoming the restricted axonal regenerative ability that limits functional repair following a
central nervous system injury remains a challenge. Here we report a regenerative paradigm …

The transcription factor forkhead box (FOXO) controls important biological responses,
including proliferation, apoptosis, differentiation, metabolism, and oxidative stress …

Cellular homeostasis in eukaryotic cells requires synchronized coordination of multiple
organelles. A key role in this stage is played by mitochondria, which have recently emerged …

HBO1 complexes are major acetyltransferase responsible for histone H4 acetylation in vivo,
which belongs to the MYST family. As the core catalytic subunit, HBO1 consists of an N …

Histone deacetylases (HDACs) play important roles in transcriptional regulation in
eukaryotic cells. Class I deacetylase HDAC1/2 often associates with repressor complexes …

Successful pregnancy necessitates that the uterus is maintained in a relaxed, quiescent
state for the majority of pregnancy, before being transformed to a contractile and excitable …