Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times.
They have enjoyed over 30 years of clinical usage and become essential tools in the …

Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

Methane fermentation is an attractive practice in waste processing, which enables one to
both control pollution and recover energy. This kind of anaerobic digestion is exposed to …

Many bacterial pathogens can permanently colonize their host and establish either chronic
or recurrent infections that the immune system and antimicrobial therapies fail to eradicate …

Mycobacterium tuberculosis possesses a large number of genes of unknown or predicted
function, undermining fundamental understanding of pathogenicity and drug susceptibility …

Fluoroquinolones, antibiotics that cause DNA damage by inhibiting DNA topoisomerases,
are clinically important, but their mechanism of action is not yet fully understood. In …

The application of forces and torques on the single molecule level has transformed our
understanding of the dynamic properties of biomolecules, but rare intermediates have …

Cancer is a very risky life-threatening disease having most formidable afflictions in the world.
Several anticancer agents are commercially accessible, however, the emergence of …

Background Quinolones have been thought to rapidly kill bacteria in two ways:(i) quinolone-
topoisomerase-DNA lesions stimulate the accumulation of toxic reactive oxygen species …

The problems of microbial infections and the emergence of drug-resistant microbes are
increasingly serious, causing countless loss of lives and economic loss. The discovery and …