Circumventing antimicrobial-resistance and preventing its development in novel, bacterial infection-control strategies

T Yu, G Jiang, R Gao, G Chen, Y Ren, J Liu… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Development of new antimicrobials with ever 'better'bacterial killing has long
been considered the appropriate response to the growing threat of antimicrobial-resistant …

[HTML][HTML] A call for action to the biomaterial community to tackle antimicrobial resistance

TJ Hall, VM Villapún, O Addison, MA Webber… - Biomaterials …, 2020 - pubs.rsc.org
The global surge of antimicrobial resistance (AMR) is a major concern for public health and
proving to be a key challenge in modern disease treatment, requiring action plans at all …

Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells

HK Alexander, RC MacLean - Proceedings of the National …, 2020 - National Acad Sciences
A better understanding of how antibiotic exposure impacts the evolution of resistance in
bacterial populations is crucial for designing more sustainable treatment strategies. The …

[HTML][HTML] Rational design of balanced dual-targeting antibiotics with limited resistance

A Nyerges, T Tomašič, M Durcik, T Revesz, P Szili… - PLoS …, 2020 - journals.plos.org
Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against
resistance evolution, but developing such antibiotics is challenging. Here we demonstrate …

Synergistic effect on anti‐methicillin‐resistant Staphylococcus aureus among combinations of α‐mangostin‐rich extract, lawsone methyl ether and ampicillin

MS Meah, M Lertcanawanichakul… - Letters in Applied …, 2020 - academic.oup.com
Abstract α‐Mangostin‐rich extract (AME) exhibited satisfactory inhibitory activities against all
tested MRSA strains, with minimum inhibitory concentrations (MICs) of 7· 8–31· 25 µ g ml− 1 …

[HTML][HTML] Developments in antibiotic-eluting scaffolds for the treatment of osteomyelitis

H Kyriacou, A Kamaraj, WS Khan - Applied Sciences, 2020 - mdpi.com
Osteomyelitis is a devastating disease caused by the infection of bone tissue and is
associated with significant morbidity and mortality. It is treated with antibiotic therapy and …

[HTML][HTML] Nisin influence on the antimicrobial resistance ability of canine oral Enterococci

E Cunha, R Janela, M Costa, L Tavares, AS Veiga… - Antibiotics, 2020 - mdpi.com
Periodontal disease (PD) is one of the most common diseases in dogs. Although previous
studies have shown the potential of the antimicrobial peptide nisin for PD control, there is no …

[HTML][HTML] Levofloxacin-ceftazidime administration regimens combat Pseudomonas aeruginosa in the hollow-fiber infection model simulating abnormal renal function in …

L Zhao, X Li, X He, L Jian - BMC Pharmacology and Toxicology, 2020 - Springer
Background The purpose of this study was to investigate the bactericidal effects of
levofloxacin and ceftazidime as both monotherapy and combination therapy, and to …

In vitro synergistic effect and mutant prevention concentrations of cefepime alone or in combination with sulbactam against OXA-48-positive Klebsiella pneumoniae …

E Mataracı-Kara, M Yılmaz, B Özbek-Çelik - Current Microbiology, 2020 - Springer
The aim of this study is to investigate the combination of cefepime and sulbactam.
Sulbactam, when administered, will effectively inhibit all Extended-spectrum beta …

Antibacterial activity of doxycycline against Aeromonas hydrophila in experimentally challenged African catfish (Clarias gariepinus)

HA Ibrahim, NZH Eleiwa, AAA Galal… - Zagazig Veterinary …, 2020 - journals.ekb.eg
Bacterial pathogens are the most serious agents causing diseases in both wild and cultured
fish resulted in massive mortalities and economic losses. Motile Aeromonas Septicemia …