Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …

The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved
mechanism to initiate rapid innate immune responses against microbial pathogens. The …

Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-
STING) pathway, is an important novel role in the immune system. Multiple STING agonists …

Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

Cancer immunotherapies enhance anti-tumor immune responses using checkpoint
inhibitors, such as PD-1 or PD-L1 inhibitors. Recent studies, however, have extended the …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …

Radiation therapy (RT) is responsible for at least 40% of cancer cures, however treatment
resistance remains a clinical problem. There have been recent advances in understanding …