[HTML][HTML] The current landscape of psoriasis genetics in 2020
Psoriasis is an immune-mediated disease associated with skin and joint inflammation that
affects large proportions of populations worldwide. It is a heritable disease: individuals' …
affects large proportions of populations worldwide. It is a heritable disease: individuals' …
GWAS in cancer: progress and challenges
B Liang, H Ding, L Huang, H Luo, X Zhu - Molecular Genetics and …, 2020 - Springer
The genome-wide association study (GWAS) is an effective method to detect single-
nucleotide polymorphisms (SNPs) of multiple individual genes based on linkage …
nucleotide polymorphisms (SNPs) of multiple individual genes based on linkage …
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis
B Nedoszytko, A Szczerkowska-Dobosz… - … in Dermatology and …, 2020 - termedia.pl
Psoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors
regulating gene expression play a key role. In the “genomic era”, genome-wide association …
regulating gene expression play a key role. In the “genomic era”, genome-wide association …
Keratinocytes derived from patient-specific induced pluripotent stem cells recapitulate the genetic signature of psoriasis disease
G Ali, AK Elsayed, M Nandakumar… - Stem cells and …, 2020 - liebertpub.com
Psoriasis is characterized by hyperproliferation and defective differentiation of keratinocytes
(KCs). Patients with psoriasis are at a high risk of developing diabetes and cardiovascular …
(KCs). Patients with psoriasis are at a high risk of developing diabetes and cardiovascular …
From genome-wide association studies to rational drug target prioritisation in inflammatory arthritis
Early identification of genetically validated drug targets can increase the chances of
successful late-stage drug development. 81 high-quality genome-wide association studies …
successful late-stage drug development. 81 high-quality genome-wide association studies …
Detecting shared genetic architecture among multiple phenotypes by hierarchical clustering of gene-level association statistics
McGuirl et al. present a new method, Ward clustering to identify Internal Node branch length
outliers using Gene Scores (WINGS), for identifying shared genetic architecture among …
outliers using Gene Scores (WINGS), for identifying shared genetic architecture among …
An integrated analysis of public genomic data unveils a possible functional mechanism of psoriasis risk via a long-range ERRFI1 enhancer
N Kubota, M Suyama - BMC Medical Genomics, 2020 - Springer
Background Psoriasis is a chronic inflammatory skin disease, for which genome-wide
association studies (GWAS) have identified many genetic variants as risk markers. However …
association studies (GWAS) have identified many genetic variants as risk markers. However …
Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis
Biological therapies have dramatically improved the therapeutic landscape of psoriatic
arthritis (PsA); however, 40–50% of patients are primary non-responders with response …
arthritis (PsA); however, 40–50% of patients are primary non-responders with response …