The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

Insulin resistance (IR), defined as an attenuated biological response to circulating insulin, is
a fundamental defect in obesity and type 2 diabetes (T2D), and is also linked to a wide …

Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …

The ability to quantify DNA, RNA, and protein variations at the single cell level has
revolutionized our understanding of cellular heterogeneity within tissues. Via such analyses …

Cell migration plays a critical role in vascular homeostasis. Under noxious stimuli,
endothelial cells (ECs) migration always contributes to vascular repair, while enhanced …

Key points This study demonstrates and evaluates the changes in rat vascular smooth
muscle cell biomechanics following statin‐mediated cholesterol depletion. Evidence is …

Objective: Abdominal aortic aneurysms (AAAs) are highly lethal diseases without effective
clinical predictors and therapeutic targets. Vascular microcalcification, as detected by …

Background Human mesenchymal cells are culprit factors in vascular (patho) physiology
and are hallmarked by phenotypic and functional heterogeneity. At present, they are …

Mechanisms whereby fibrillin-1 mutations determine thoracic aorta aneurysms/dissections
(TAAD) in Marfan Syndrome (MFS) are unclear. Most aortic aneurysms evolve from …

Vascular calcification, which involves the deposition of calcifying particles within the arterial
wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes …