Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology
The complex pathophysiology of autism spectrum disorder encompasses interactions
between genetic and environmental factors. On the one hand, hundreds of genes …
between genetic and environmental factors. On the one hand, hundreds of genes …
Glial cells in schizophrenia: a unified hypothesis
The cellular neurobiology of schizophrenia remains poorly understood. We discuss
neuroimaging studies, pathological findings, and experimental work supporting the idea that …
neuroimaging studies, pathological findings, and experimental work supporting the idea that …
Longitudinal assessment of mental health disorders and comorbidities across 4 decades among participants in the Dunedin birth cohort study
Importance Mental health professionals typically encounter patients at 1 point in patients'
lives. This cross-sectional window understandably fosters focus on the current presenting …
lives. This cross-sectional window understandably fosters focus on the current presenting …
[HTML][HTML] Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism
We present the largest exome sequencing study of autism spectrum disorder (ASD) to date
(n= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …
(n= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …
[HTML][HTML] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
(AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples …
Validity and utility of hierarchical taxonomy of psychopathology (HiTOP): I. Psychosis superspectrum
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes
INTRODUCTION Human genetic studies have revealed long lists of genes and loci
associated with risk for many diseases and disorders, but to systematically evaluate their …
associated with risk for many diseases and disorders, but to systematically evaluate their …
Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional …
understood due to the high complexity of affected neuronal circuits. To identify dysfunctional …
Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder
Major depressive disorder emerges from the complex interactions of biological systems that
span genes and molecules through cells, networks, and behavior. Establishing how …
span genes and molecules through cells, networks, and behavior. Establishing how …
The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …