Drug resistance developed towards conventional therapy is one of the important reasons for
chemotherapy failure in cancer. The various underlying mechanism for drug resistance …

Significance: The p53 tumor suppressor has been dubbed the “guardian of genome”
because of its various roles in the response to DNA damage such as DNA damage repair …

Abstract CDK2 (cyclin-dependent kinase 2), a member of the CDK family, has been shown
to play a role in many cellular activities including cell cycle progression, apoptosis and …

Background DNA damage response (DDR) genomic alterations may play an important role
in clinical outcomes of patients with urothelial cancer (UC). However, data on the prognostic …

Therapeutic targeting of the DNA damage response in prostate... : Current Opinion in Oncology
Therapeutic targeting of the DNA damage response in prostate cancer : Current Opinion in …

Whole human genome microarray was performed to identify the potential molecular
mechanisms associated with phospholipase C epsilon (PLCε). Gene Ontology, Kyoto …

Multiple myeloma (MM) is an incurable hematological malignancy, for which novel effective
therapies are urgently needed. We synthesized a novel phosphoramide compound …

Increasing evidence suggests that interference with growth factor receptor tyrosine kinase
(RTK) signaling can affect DNA damage response (DDR) networks, with a consequent …

Objective In this study, we used HepG2 human hepatocellular carcinoma cells to study the
effects of Compound Xishu Granule (CXG) on cell proliferation, apoptosis, and the cell cycle …

The outcome of inoperable rectal cancer treatment by chemotherapy, radiotherapy, and
targeted therapy are still unfavorable. Carbogen is a combination of 98% oxygen and 2 …