Patients over the age 65 are a quickly expanding segment of the US population and
represent a large percentage of patients requiring inpatient care. Older adults are more …

By numerous measures, opioid-related harm in the United States has been increasing over
the past 2 decades. Rates of opioid misuse and overdose have reached new highs in recent …

Importance It is not known whether decreases in Schedule II (high abuse potential) vs
Schedule IV (lower abuse potential) opioid prescriptions overall and among high-risk …

Tramadol and tapentadol are fully synthetic and extensively used analgesic opioids,
presenting enhanced therapeutic and safety profiles as compared with their peers. However …

Dose titration with immediate-release opioids is currently recommended for acute pain. The
Australian and New Zealand College of Anaesthetists and the Faculty of Pain Medicine …

Background and aims Despite increases in opioid prescribing and related morbidity and
mortality, few studies have comprehensively documented harms across opioid types. We …

Background Tapentadol is a molecule incorporating mu opioid receptor agonism and
norepinephrine reuptake inhibition to provide analgesia, with the potential for a lower …

Background Controlling postoperative pain after spinal surgery is important for rehabilitation
and patient satisfaction. Wound infiltration with local anesthetics may improve postoperative …

Tramadol is widely used globally and is the second most prescribed opioid in the United
States. It treats moderate to severe pain but lethal opioid-induced respiratory depression is …

Objective: To compare concomitant benzodiazepine (BZDs) use among chronic pain
patients adherent to extended-release tapentadol (TapER) or oxycodone (OxnER) and …