The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Aging is the main risk factor for vascular disease and ensuing cardiovascular and
cerebrovascular events, the leading causes of death worldwide. In a progressively aging …

Differences in immune function and responses contribute to health-and life-span disparities
between sexes. However, the role of sex in immune system aging is not well understood …

Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …

Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …

Biological age measurements (BAs) assess aging-related physiological change and predict
health risks among individuals of the same chronological age (CA). Multiple BAs have been …

Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

BACKGROUND Current methods for the detection and surveillance of bladder cancer (BCa)
are often invasive and/or possess suboptimal sensitivity and specificity, especially in early …

The exposome concept refers to the totality of exposures from a variety of external and
internal sources including chemical agents, biological agents, or radiation, from conception …