Numerous epidemiological and animal studies disclosed that birth weight is inversely
associated with the incidence of the lifestyle-related disorders in adult life, such as …

The perinatal period is a time of fast physiological change, including epigenetic
programming. Adverse events may lead to epigenetic changes, with implications for health …

Early life is an important window of opportunity to improve health across the full lifecycle. An
accumulating body of evidence suggests that exposure to adverse stressors during early life …

Motivation Deep neural network (DNN) algorithms were utilized in predicting various
biomedical phenotypes recently, and demonstrated very good prediction performances …

Background DNA methylation has been shown to be associated with adiposity in adulthood.
However, whether similar DNA methylation patterns are associated with childhood and …

Background Preterm birth and shorter duration of pregnancy are associated with increased
morbidity in neonatal and later life. As the epigenome is known to have an important role …

Abstract Purpose of Review This article introduces the roles of perinatal DNA methylation in
human health and disease, highlights the challenges of tissue and cellular heterogeneity to …

Particulate matter≤ 2.5 μm (PM 2.5) air pollution is a leading environmental risk factor
contributing disproportionately to the global burden of non-communicable disease. We …

Background Birthweight marks an important milestone of health across the lifespan,
including cardiometabolic disease risk in later life. The placenta, a transient organ at the …

Background Birthweight reflects in utero exposures and later health evolution. Despite
existing studies employing high-dimensional molecular measurements, the understanding …