Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …

Development of improved approaches for HIV-1 prevention will likely be required for a
durable end to the global AIDS pandemic. Recent advances in preclinical studies and early …

Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global
health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 …

Zika virus (ZIKV) has caused significant disease, with widespread cases of neurological
pathology and congenital neurologic defects. Rapid vaccine development has led to a …

Antibodies targeting the V1V2 apex of the HIV-1 envelope (Env) trimer comprise one of the
most commonly elicited categories of broadly neutralizing antibodies. Structures of these …

Today, vaccinologists have come to understand that the hallmark of any protective immune
response is the antigen. However, it is not the whole antigen that dictates the immune …

The HIV reservoir remains to be a difficult barrier to overcome in order to achieve a
therapeutic cure for HIV. Several strategies have been developed to purge the reservoir …

Natural infections and vaccination with a pathogen typically stimulate the production of
potent antibodies specific for the pathogen through a Darwinian evolutionary process known …

During HIV-1 entry into target cells, binding of the virus to host receptors, CD4 and
CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env) …

Persistent viral infections subvert key elements of adaptive immunity. To compare germinal
center (GC) B cell responses in chronic and acute lymphocytic choriomeningitis virus …