Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

A Khan, M Ikram, JR Hahm, MO Kim - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders have emerged as a serious health issue in the current era.
The most common neurodegenerative disorders are Alzheimer's disease (AD), Parkinson's …

Cadmium-induced oxidative stress: focus on the central nervous system

JJV Branca, C Fiorillo, D Carrino, F Paternostro… - Antioxidants, 2020 - mdpi.com
Cadmium (Cd), a category I human carcinogen, is a well-known widespread environmental
pollutant. Chronic Cd exposure affects different organs and tissues, such as the central …

Protocatechuic acid mitigates cadmium-induced neurotoxicity in rats: Role of oxidative stress, inflammation and apoptosis

EM Al Olayan, AS Aloufi, OD AlAmri, H Ola… - Science of the total …, 2020 - Elsevier
Environmental and occupational exposure to heavy metals, including cadmium (Cd), is
associated with extremely adverse impacts to living systems. Antioxidant agents are …

Antioxidant and neuroprotective effects of caffeine against Alzheimer's and Parkinson's disease: Insight into the role of Nrf-2 and A2AR signaling

M Ikram, TJ Park, T Ali, MO Kim - Antioxidants, 2020 - mdpi.com
This paper reviews the results of studies conducted on the role of caffeine in the
management of different neurological disorders, such as Parkinson's disease (PD) and …

Oral administration of alpha linoleic acid rescues Aβ-induced glia-mediated neuroinflammation and cognitive dysfunction in C57BL/6N mice

W Ali, M Ikram, HY Park, MG Jo, R Ullah, S Ahmad… - Cells, 2020 - mdpi.com
In this work, we evaluated the effects of alpha linoleic acid (ALA), an omega-3
polyunsaturated fatty acid, on amyloid-beta-induced glial-cell-mediated neuroinflammation …

Caffeine targets SIRT3 to enhance SOD2 activity in mitochondria

H Xu, C Gan, Z Gao, Y Huang, S Wu… - Frontiers in Cell and …, 2020 - frontiersin.org
Caffeine is chemically stable and not readily oxidized under normal physiological conditions
but also has antioxidant effects, although the underlying molecular mechanism is not well …

Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK …

R Hao, X Song, F Li, X Tan, D Sun-Waterhouse… - Food and Chemical …, 2020 - Elsevier
Exposure to nonbiodegradable cadmium (Cd) causes many health problems including the
damage to the nervous system. This study aimed to increase knowledge about its neurotoxic …

The role of dietary antioxidants in the pathogenesis of neurodegenerative diseases and their impact on cerebral oxidoreductive balance

A Winiarska-Mieczan, E Baranowska-Wójcik… - Nutrients, 2020 - mdpi.com
Neurodegenerative diseases are progressive diseases of the nervous system that lead to
neuron loss or functional disorders. Neurodegenerative diseases require long-term …

Inhibition of JNK Alleviates Chronic Hypoperfusion‐Related Ischemia Induces Oxidative Stress and Brain Degeneration via Nrf2/HO‐1 and NF‐κB Signaling

MS Khan, A Khan, S Ahmad, R Ahmad… - Oxidative Medicine …, 2020 - Wiley Online Library
Cerebral ischemia is one of the leading causes of neurological disorders. The exact
molecular mechanism related to chronic unilateral cerebral ischemia‐induced …

Metabolic stress alters antioxidant systems, suppresses the adiponectin receptor 1 and induces Alzheimer's like pathology in mice brain

JR Hahm, MH Jo, R Ullah, MW Kim, MO Kim - Cells, 2020 - mdpi.com
Oxidative stress and insulin resistance play major roles in numerous neurodegenerative
diseases, including Alzheimer's disease (AD). A high-fat diet induces obesity-associated …