Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis

E Di Maria, A Latini, P Borgiani, G Novelli - Human genomics, 2020 - Springer
The COVID-19 pandemic has strengthened the interest in the biological mechanisms
underlying the complex interplay between infectious agents and the human host. The …

Pharmacogenomics of COVID-19 therapies

T Takahashi, JA Luzum, MR Nicol… - NPJ genomic …, 2020 - nature.com
A new global pandemic of coronavirus disease 2019 (COVID-19) has resulted in high
mortality and morbidity. Currently numerous drugs are under expedited investigations …

Genetic polymorphisms associated with rheumatoid arthritis development and antirheumatic therapy response

DS Mikhaylenko, MV Nemtsova, IV Bure… - International journal of …, 2020 - mdpi.com
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy worldwide. Possible
manifestations of RA can be represented by a wide variability of symptoms, clinical forms …

Host genetics at the intersection of autoimmunity and COVID-19: a potential key for heterogeneous COVID-19 severity

T Karaderi, H Bareke, I Kunter, A Seytanoglu… - Frontiers in …, 2020 - frontiersin.org
COVID-19 presentation is very heterogeneous across cases, and host factors are at the
forefront for the variables affecting the disease manifestation. The immune system has …

Important pharmacogenetic information for drugs prescribed during the SARS‐CoV‐2 infection (COVID‐19)

P Zubiaur, D Koller, M Saiz‐Rodríguez… - Clinical and …, 2020 - Wiley Online Library
In December 2019, the severe acute respiratory syndrome virus‐2 pandemic began,
causing the coronavirus disease 2019. A vast variety of drugs is being used off‐label as …

The evolution in our understanding of the genetics of rheumatoid arthritis and the impact on novel drug discovery

F Machaj, J Rosik, B Szostak… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by
chronic inflammation of the joints and affects 1% of the population. Polymorphisms of genes …

Polymorphisms involved in response to biological agents used in rheumatoid arthritis

G Pallio, F Mannino, N Irrera, AH Eid, F Squadrito… - Biomolecules, 2020 - mdpi.com
Rheumatoid arthritis (RA) is a systemic disease that leads to joint destruction. During the last
decade, the therapy of RA has been principally based on biological drugs. Although the …

Impact of Single-Nucleotide Polymorphisms of CTLA-4, CD80 and CD86 on the Effectiveness of Abatacept in Patients with Rheumatoid Arthritis

N Marquez Pete, MM Maldonado Montoro… - Journal of Personalized …, 2020 - mdpi.com
Abatacept (ABA) is used as a first-line treatment in patients diagnosed with moderate and
severe rheumatoid arthritis (RA). The interindividual response to ABA therapy is very …

[HTML][HTML] TREATMENT RESPONSE PREDICTION IN PATIENTS WITH RHEUMATOID ARTHRITIS. Review

DL Fedkov, MO Komkina - Medical Science of Ukraine (MSU), 2020 - msu-journal.com
Relevance. A variety of targeted therapies for rheumatoid arthritis (RA) treatment exist.
Therefore, reliable predictors are needed that could be used to accurately predict the …

[PDF][PDF] Interleukin 6 (IL6) Level is a Biomarker for Functional Disease Progression Within IL6R358Ala Variant Groups in Amyotrophic Lateral Sclerosis Patients

C Milligan - IL6 TRANSSIGNALING AND THE IL6R …, 2020 - wakespace.lib.wfu.edu
Abstract Interleukin-6 (IL6) expression increases in atrophying muscles and lung tissue
during compromised function. Considering ALS patients undergo these same pathological …