Single‐cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy
S Ding, X Chen, K Shen - Cancer Communications, 2020 - Wiley Online Library
Single‐cell RNA sequencing (scRNA‐seq) is a novel technology that allows transcriptomic
analyses of individual cells. During the past decade, scRNA‐seq sensitivity, accuracy, and …
analyses of individual cells. During the past decade, scRNA‐seq sensitivity, accuracy, and …
Tumor functional heterogeneity unraveled by scRNA-seq technologies
L González-Silva, L Quevedo, I Varela - Trends in cancer, 2020 - cell.com
Effective cancer treatment has been precluded by the presence of various forms of
intratumoral complexity that drive treatment resistance and metastasis. Recent single-cell …
intratumoral complexity that drive treatment resistance and metastasis. Recent single-cell …
Single-cell network biology for resolving cellular heterogeneity in human diseases
Understanding cellular heterogeneity is the holy grail of biology and medicine. Cells
harboring identical genomes show a wide variety of behaviors in multicellular organisms …
harboring identical genomes show a wide variety of behaviors in multicellular organisms …
[PDF][PDF] DUX-miR-344-ZMYM2-mediated activation of MERVL LTRs induces a totipotent 2C-like state
Mouse embryonic stem cells (ESCs) sporadically express preimplantation two-cell-stage
(2C) transcripts, including MERVL endogenous retrovirus and Zscan4 cluster genes. Such …
(2C) transcripts, including MERVL endogenous retrovirus and Zscan4 cluster genes. Such …
CMF-Impute: an accurate imputation tool for single-cell RNA-seq data
Motivation Single-cell RNA-sequencing (scRNA-seq) technology provides a powerful tool for
investigating cell heterogeneity and cell subpopulations by allowing the quantification of …
investigating cell heterogeneity and cell subpopulations by allowing the quantification of …
[PDF][PDF] A single-cell transcriptomics CRISPR-activation screen identifies epigenetic regulators of the zygotic genome activation program
C Alda-Catalinas, D Bredikhin, I Hernando-Herraez… - Cell systems, 2020 - cell.com
Zygotic genome activation (ZGA) is an essential transcriptional event in embryonic
development that coincides with extensive epigenetic reprogramming. Complex …
development that coincides with extensive epigenetic reprogramming. Complex …
DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes
Preimplantation embryos experience profound resetting of epigenetic information inherited
from the gametes. Genome-wide analysis at single-base resolution has shown similarities …
from the gametes. Genome-wide analysis at single-base resolution has shown similarities …
A transcriptional roadmap for 2C-like–to–pluripotent state transition
In mouse embryonic stem cell (ESC), a small cell population displays totipotent features by
expressing a set of genes that are transiently active in 2-cell–stage embryos. These 2-cell …
expressing a set of genes that are transiently active in 2-cell–stage embryos. These 2-cell …
Does growth hormone supplementation improve oocyte competence and IVF outcomes in patients with poor embryonic development? A randomized controlled trial
J Li, Q Chen, J Wang, G Huang, H Ye - BMC pregnancy and childbirth, 2020 - Springer
Background Many studies have demonstrated the benefits of the addition of growth hormone
(GH) to the controlled ovarian stimulation protocol in vitro fertilization (IVF) cycles in poor …
(GH) to the controlled ovarian stimulation protocol in vitro fertilization (IVF) cycles in poor …
Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG–derived small RNAs present in mature spermatozoa
X Chen, Y Zheng, A Lei, H Zhang, H Niu, X Li… - Journal of Biological …, 2020 - ASBMB
tRNA-derived small RNAs (tsRNAs) from spermatozoa could act as acquired epigenetic
factors and contribute to offspring phenotypes. However, the roles of specific tsRNAs in early …
factors and contribute to offspring phenotypes. However, the roles of specific tsRNAs in early …