Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …

ABSTRACT Introduction: Aicardi-Goutières syndrome (AGS) is the prototype of the type I
interferonopathies, a new heterogeneous group of autoinflammatory disorders in which type …

Apart from acute and chronic blood pressure lowering, we have no specific medications to
prevent intracerebral haemorrhage (ICH) or improve outcomes once bleeding has occurred …

The anti-leukemia agent forodesine causes cytotoxic overload of intracellular
deoxyguanosine triphosphate (dGTP) but is efficacious only in a subset of patients. We …

Ribonucleotides (rNMPs) incorporated in the nuclear genome are a well-established threat
to genome stability and can result in DNA strand breaks when not removed in a timely …

IFNs are well known as mediators of the antimicrobial response but also serve as important
immunomodulatory cytokines in autoimmune and autoinflammatory diseases. An …

Monogenic type I interferonopathies are inherited heterogeneous disorders characterised by
early onset of systemic and organ specific inflammation, associated with constitutive …

In mammalian cells, the catabolic activity of the dNTP triphosphohydrolase SAMHD1 sets
the balance and concentration of the four dNTPs. Deficiency of SAMHD1 leads to unequally …

Autoimmunity can result when cells fail to properly dispose of DNA. Mutations in the three-
prime repair exonuclease 1 (TREX1) cause a spectrum of human autoimmune diseases …

Different members of the tetraspanin superfamily have been described to regulate different
virus infectious cycles at several stages: viral entry, viral replication or virion exit or infectivity …