In the past five years, pluripotent stem cell (PSC)-derived kidney organoids and adult stem
or progenitor cell (ASC)-based kidney tubuloids have emerged as advanced in vitro models …

Kidney organoids derived from human induced pluripotent stem cells bear the potential to
be used as a regenerative medicine renal replacement therapy. Advances in developmental …

Development of the metanephric kidney is strongly dependent on complex signaling
pathways and cell–cell communication between at least four major progenitor cell …

The kidney is a key organ in the human body that excretes toxins and sustains the water–
electrolyte balance. During embryonic development and disease progression, the kidney …

As organoids offer a promising tool to study cell biology and model diseases, organoid
technology has rapidly evolved over the last few years. Even though intestinal organoids are …

In vitro models represent a critical tool in cancer research to study tumor biology and to
evaluate new treatment options. Unfortunately, there are no effective preclinical models …

Kidney organoids represent a physiologically advanced model for studying the mechanisms
of kidney development and disease. Here, we describe a simple two-step protocol for the …

The class of human genetic kidney diseases is extremely broad and heterogeneous.
Accordingly, the range of associated disease phenotypes is highly variable. Many children …

The formation of three-dimensional kidney tissue (organoids) from human pluripotent stem
cell lines provides a valuable tool to examine kidney function in an in vitro model and could …

With recent advances in stem cell research, human pluripotent stem cells have been
successfully differentiated into self-organizing tissues called 'organoids'. The cells and their …