[HTML][HTML] More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
The relationship between intestinal goblet cells and the immune response
M Zhang, C Wu - Bioscience Reports, 2020 - portlandpress.com
Goblet cells (GCs) are single-cell glands that produce and secrete mucin. Mucin forms a
mucus layer, which can separate the materials in cavities from the intestinal epithelium and …
mucus layer, which can separate the materials in cavities from the intestinal epithelium and …
[HTML][HTML] Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract
The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
[HTML][HTML] Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium
SP Sajuthi, P DeFord, Y Li, ND Jackson… - Nature …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging
virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the …
virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the …
[HTML][HTML] Single-cell and population transcriptomics reveal pan-epithelial remodeling in type 2-high asthma
ND Jackson, JL Everman, M Chioccioli, L Feriani… - Cell reports, 2020 - cell.com
The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus
obstruction of the airways. To further investigate this incompletely understood pathobiology …
obstruction of the airways. To further investigate this incompletely understood pathobiology …
[HTML][HTML] Generation of a single-cell RNAseq atlas of murine salivary gland development
Understanding the dynamic transcriptional landscape throughout organ development will
provide a template for regenerative therapies. Here, we generated a single-cell RNA …
provide a template for regenerative therapies. Here, we generated a single-cell RNA …
[HTML][HTML] Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium
SP Sajuthi, P DeFord, ND Jackson, MT Montgomery… - Biorxiv, 2020 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) outcomes vary from asymptomatic infection
to death. This disparity may reflect different airway levels of the SARS-CoV-2 receptor …
to death. This disparity may reflect different airway levels of the SARS-CoV-2 receptor …
Stem cells and lung regeneration
The ability to replace defective cells in an airway with cells that can engraft, integrate, and
restore a functional epithelium could potentially cure a number of lung diseases. Progress …
restore a functional epithelium could potentially cure a number of lung diseases. Progress …
Using single-cell RNA sequencing to unravel cell lineage relationships in the respiratory tract
LE Zaragosi, M Deprez, P Barbry - Biochemical Society …, 2020 - portlandpress.com
The respiratory tract is lined by a pseudo-stratified epithelium from the nose to terminal
bronchioles. This first line of defense of the lung against external stress includes five main …
bronchioles. This first line of defense of the lung against external stress includes five main …
Immune-Goblet cell interaction in the conjunctiva
J Alam, CS de Paiva, SC Pflugfelder - The ocular surface, 2020 - Elsevier
The conjunctiva is a goblet cell rich mucosal tissue. Goblet cells are supported by tear
growth factors and IL-13 produced by resident immune cells. Goblet cell secretions are …
growth factors and IL-13 produced by resident immune cells. Goblet cell secretions are …