[HTML][HTML] Potential therapeutic options for COVID-19: current status, challenges, and future perspectives

C Sarkar, M Mondal, M Torequl Islam… - Frontiers in …, 2020 - frontiersin.org
The COVID-19 pandemic represents an unprecedented challenge for the researchers to
offer safe, tolerable, and effective treatment strategies for its causative agent known as …

Target organ toxicity

PK Gupta, PK Gupta - Problem Solving Questions in Toxicology: A Study …, 2020 - Springer
Several target organs such as liver, kidney, lungs, heart, ocular and visual apparatus, skin,
reproductive organ, immune system, endocrine systems, etc. play an important role for …

[HTML][HTML] Review of burden, clinical definitions, and management of COVID-19 cases

L McArthur, D Sakthivel, R Ataide, F Chan… - The American journal …, 2020 - ncbi.nlm.nih.gov
Our understanding of SARS-CoV-2, the virus responsible for coronavirus disease 2019
(COVID-19), its clinical manifestations, and treatment options continues to evolve at an …

[HTML][HTML] MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to …

L Zhou, K Huntington, S Zhang, L Carlsen, EY So… - Oncotarget, 2020 - ncbi.nlm.nih.gov
COVID-19 affects vulnerable populations including elderly individuals and patients with
cancer. Natural Killer (NK) cells and innate-immune TRAIL suppress transformed and virally …

Nanoparticles‐assisted delivery of antiviral‐siRNA as inhalable treatment for human respiratory viruses: A candidate approach against SARS‐COV‐2

A Ullah, J Qazi, L Rahman, AG Kanaras… - Nano …, 2020 - Wiley Online Library
The current pandemic of coronavirus disease 2019 (COVID‐19) caused by severe acute
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has challenged healthcare structures …

[HTML][HTML] Complexities of diagnosis and management of COVID-19 in autoimmune diseases: Potential benefits and detriments of immunosuppression

T Georgiev, AK Angelov - World journal of clinical cases, 2020 - ncbi.nlm.nih.gov
Recent advances in our understanding of coronavirus disease 2019 (COVID-19) and the
associated acute respiratory distress syndrome might approximate the cytokine release …

[HTML][HTML] COVID‑19 in China: From epidemiology to treatment

H Chen, S Wu, X Zhang - … and Therapeutic Medicine, 2020 - spandidos-publications.com
Abstract Coronavirus disease 2019 (COVID‑19) is a newly emerging infectious disease
caused by the novel coronavirus SARS‑CoV‑2. It first became prevalent in Wuhan, Hubei …

[HTML][HTML] Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of …

L Zhou, K Huntington, S Zhang, L Carlsen, EY So… - Biorxiv, 2020 - ncbi.nlm.nih.gov
COVID-19 affects vulnerable populations including elderly individuals and patients with
cancer. Natural Killer (NK) cells and innate-immune TRAIL suppress transformed and virally …

[PDF][PDF] A review on the fifth pandemic: coronavirus

K Navdeep, K Simranpreet, K Manjinder - Asian J Pharm Clin Res, 2020 - academia.edu
Since the 1918 flu pandemic, the novel human coronavirus outbreak COVID-19 has been
the fifth known pandemic. COVID-19 was first identified in Wuhan, China, and later spread …

Clinical guidance and the delivery of care for patients with coronavirus disease 2019

RR Razonable, EM Carmona… - Mayo Clinic …, 2020 - mayoclinicproceedings.org
Coronavirus disease 2019 (COVID-19) is challenging medical communities worldwide. As
the contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …