Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three malignancies—
Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's …

DNA has been known to be a potent immune stimulus for more than half a century. However,
the underlying molecular mechanisms of DNA-triggered immune response have remained …

Highlights•Pathogens evade cytosolic DNA sensing using divergent and overlapping
strategies to target cGAS, 2′ 3′-cGAMP, and STING.•Studies of pathogen mechanisms of …

The human DNA tumor viruses Epstein–Barr virus (EBV), Kaposi's sarcoma-associated
herpesvirus (KSHV), and human papillomavirus (HPV) share the common property of …

Cell‐autonomous sensing of nucleic acids is essential for host defence against invading
pathogens by inducing antiviral and inflammatory cytokines. cGAS has emerged in recent …

Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is associated with KS, primary
effusion lymphoma (PEL), and multicentric Castleman disease (MCD). To ensure its own …

Kaposi's sarcoma herpesvirus (KSHV) is an oncogenic human virus and the leading cause
of mortality in HIV infection. KSHV reactivation from latent-to lytic-stage infection initiates a …

Cyclic dinucleotides (CDNs) have emerged as ubiquitous signaling molecules in all
domains of life. In eukaryotes, CDN signaling systems are evolutionarily ancient and have …