Inflammation, frailty and cardiovascular disease
Chronic inflammation, which is called “inflamm-aging”, is characterized by an increased
level of inflammatory cytokines in response to physiological and environmental stressors …
level of inflammatory cytokines in response to physiological and environmental stressors …
T cells, aging and senescence
L Pangrazzi, B Weinberger - Experimental Gerontology, 2020 - Elsevier
The T cell compartment undergoes characteristic changes with age, which contribute to
increased incidence and severity of infections and reduced immunogenicity and efficacy of …
increased incidence and severity of infections and reduced immunogenicity and efficacy of …
SARS-CoV-2-specific T cells exhibit phenotypic features of helper function, lack of terminal differentiation, and high proliferation potential
Summary Convalescing coronavirus disease 2019 (COVID-19) patients mount robust T cell
responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance …
responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance …
The conundrum of human immune system “senescence”
There is a great deal of debate on the question of whether or not we know what ageing is
(Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused …
(Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused …
The human immunosenescence phenotype: does it exist?
G Pawelec - Seminars in Immunopathology, 2020 - Springer
Abstract “Immunosenescence” has been invoked as the root cause of increased incidence
and severity of infectious disease in older adults and their poorer response to vaccination …
and severity of infectious disease in older adults and their poorer response to vaccination …
SARS-CoV-2-specific T cells exhibit unique features characterized by robust helper function, lack of terminal differentiation, and high proliferative potential
Convalescing COVID-19 patients mount robust T cell responses against SARS-CoV-2,
suggesting an important role for T cells in viral clearance. To date, the phenotypes of SARS …
suggesting an important role for T cells in viral clearance. To date, the phenotypes of SARS …
Role of the nuclear lamina in age-associated nuclear reorganization and inflammation
L Kristiani, M Kim, Y Kim - Cells, 2020 - mdpi.com
Aging is characterized by the gradual loss of tissue function and integrity. Activation of
inflammatory responses accelerates the deterioration of cells and tissues. Many studies …
inflammatory responses accelerates the deterioration of cells and tissues. Many studies …
[HTML][HTML] Understanding the mechanism of action of cytomegalovirus-induced regulatory T cells
A Tovar-Salazar, A Weinberg - Virology, 2020 - Elsevier
We previously showed that CMV-induced CD4+ CD27− CD28− T cells have regulatory
(Treg) function. Here we sought to identify the target/s and the mechanistic underpinning/s of …
(Treg) function. Here we sought to identify the target/s and the mechanistic underpinning/s of …
Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection
Major depressive disorder (MDD) is associated with physiological changes commonly
observed with increasing age, such as inflammation and impaired immune function. Age …
observed with increasing age, such as inflammation and impaired immune function. Age …
[HTML][HTML] Pathogenic load and frailty in older adults: Singapore longitudinal ageing study
TP Ng, Y Lu, CTY Tan, Q Gao, X Gwee, T Fulop… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Human evidence for the role of continuous antigenic stimulation from persistent latent
infections in frailty is limited. We conducted a nested case-control study (99 deceased and …
infections in frailty is limited. We conducted a nested case-control study (99 deceased and …