It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

Senescent cells accumulate with age in vertebrates and promote aging largely through their
senescence‐associated secretory phenotype (SASP). Many types of stress induce …

Chromosomal instability (CIN) is associated with many human diseases, including
neurodevelopmental or neurodegenerative conditions, age-related disorders and cancer …

Adipose tissue as the largest energy reservoir and endocrine organ is essential for
maintenance of systemic glucose, lipid and energy homeostasis, but these metabolic …

Cerebrovascular endothelial cells (CECs) are integral components of both the blood‐brain
barrier (BBB) and the neurovascular unit (NVU). As the primary cell type of the BBB, CECs …

The adult central nervous system (CNS) contains resident stem cells within specific niches
that maintain a self-renewal and proliferative capacity to generate new neurons, astrocytes …

Infertility affects 10% of reproductive-age women and is extremely heterogeneous in
etiology. The genetic contribution to female infertility is incompletely understood, and …

Accumulation of senescent cells has a causative role in the pathology of age-related
disorders including atherosclerosis (AS) and cardiovascular diseases (CVDs). However, the …