Role of human leukocyte antigen system as a predictive biomarker for checkpoint-based immunotherapy in cancer patients
Recent advances in cancer immunotherapy have clearly shown that checkpoint-based
immunotherapy is effective in a small subgroup of cancer patients. However, no effective …
immunotherapy is effective in a small subgroup of cancer patients. However, no effective …
Importance of the major histocompatibility complex (swine leukocyte antigen) in swine health and biomedical research
SE Hammer, CS Ho, A Ando… - Annual review of …, 2020 - annualreviews.org
In pigs, the major histocompatibility complex (MHC), or swine leukocyte antigen (SLA)
complex, maps to Sus scrofa chromosome 7. It consists of three regions, the class I and …
complex, maps to Sus scrofa chromosome 7. It consists of three regions, the class I and …
Ipd-imgt/hla database
J Robinson, DJ Barker, X Georgiou… - Nucleic acids …, 2020 - academic.oup.com
Abstract The IPD-IMGT/HLA Database, http://www. ebi. ac. uk/ipd/imgt/hla/, currently
contains over 25 000 allele sequence for 45 genes, which are located within the Major …
contains over 25 000 allele sequence for 45 genes, which are located within the Major …
HLA allele frequencies and susceptibility to COVID‐19 in a group of 99 Italian patients
A Novelli, M Andreani, M Biancolella, L Liberatoscioli… - Hla, 2020 - Wiley Online Library
With the aim to individuate alleles that may reflect a higher susceptibility to the disease, in
the present study we analyzed the HLA allele frequency distribution in a group of 99 Italian …
the present study we analyzed the HLA allele frequency distribution in a group of 99 Italian …
iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function
P Ni, H Noh, GH Park, Z Shao, Y Guan, JM Park… - Molecular …, 2020 - nature.com
Schizophrenia (SCZ) is a neurodevelopmental disorder. Thus, studying pathogenetic
mechanisms underlying SCZ requires studying the development of brain cells. Cortical …
mechanisms underlying SCZ requires studying the development of brain cells. Cortical …
Major histocompatibility complex-associated odour preferences and human mate choice: near and far horizons
J Havlíček, J Winternitz… - … Transactions of the …, 2020 - royalsocietypublishing.org
The major histocompatibility complex (MHC) is a core part of the adaptive immune system.
As in other vertebrate taxa, it may also affect human chemical communication via odour …
As in other vertebrate taxa, it may also affect human chemical communication via odour …
HLAs, TCRs, and KIRs, a triumvirate of human cell-mediated immunity
Z Djaoud, P Parham - Annual Review of Biochemistry, 2020 - annualreviews.org
In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a
peptide and take it to the cell surface for surveillance by lymphocytes. These include natural …
peptide and take it to the cell surface for surveillance by lymphocytes. These include natural …
A diploid assembly-based benchmark for variants in the major histocompatibility complex
Most human genomes are characterized by aligning individual reads to the reference
genome, but accurate long reads and linked reads now enable us to construct accurate …
genome, but accurate long reads and linked reads now enable us to construct accurate …
A genome-wide association study identifies two novel susceptible regions for squamous cell carcinoma of the head and neck
To identify genetic variants for risk of squamous cell carcinoma of the head and neck
(SCCHN), we conducted a two-phase genome-wide association study consisting of …
(SCCHN), we conducted a two-phase genome-wide association study consisting of …
The unconventional role of HLA-E: The road less traveled
Abstract Histocompatibility Leukocyte Antigens, or HLAs, are one of the most polymorphic
molecules in humans. This high degree of polymorphism endows HLA molecules with the …
molecules in humans. This high degree of polymorphism endows HLA molecules with the …