Aging is a biological phenomenon in which the structure and function of organisms declining
with the increasing of age. It has become a major risk factor of human diseases, including …

Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

NAD+, a co-enzyme involved in a great deal of biochemical reactions, has been found to be
a network node of diverse biological processes. In mammalian cells, NAD+ is synthetized …

Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is
present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of …

Sirtuin 6 (SIRT6) is a nuclear NAD+-dependent deacetylase of histone H3 that regulates
genome stability and gene expression. However, nonhistone substrates and additional …

One of the biochemical abnormalities found in diabetic tissues is a decrease in the cytosolic
oxidized to reduced forms of the nicotinamide adenine dinucleotide ratio (NAD+/NADH also …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
preferential death of motor neurons. Approximately 10% of ALS cases are familial and 90 …

Endoplasmic reticulum (ER) stress is an evolutionarily conserved adaptive response that
contributes to deal with the misfolded or unfolded protein in the lumen of the ER and restore …

Doxorubicin (DOX) continues to attract the interest of preclinical and clinical investigations
despite its longer-than-50-year record of longevity. The clinical application of DOX can be …