AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation
JL Van Nostrand, K Hellberg, EC Luo… - Genes & …, 2020 - genesdev.cshlp.org
Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the
biguanide drug metformin are still being discovered. In particular, the detailed molecular …
biguanide drug metformin are still being discovered. In particular, the detailed molecular …
Metformin enhances the immunomodulatory potential of adipose-derived mesenchymal stem cells through STAT1 in an animal model of lupus
SG Jang, J Lee, SM Hong, SK Kwok, ML Cho… - …, 2020 - academic.oup.com
Abstract Objectives Mesenchymal stem cells (MSCs) are considered potential therapeutic
agents for treating autoimmune disease because of their immunomodulatory capacities and …
agents for treating autoimmune disease because of their immunomodulatory capacities and …
IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium
K Peng, X Fan, Q Li, Y Wang, X Chen, P Xiao… - Journal of molecular and …, 2020 - Elsevier
Aims Mammalian target of rapamycin (mTOR) inhibitors used in drug-eluting stents (DES) to
control restenosis have been found to delay endothelialization and increase incidence of …
control restenosis have been found to delay endothelialization and increase incidence of …
High expression of IGBP1 correlates with poor prognosis in esophageal squamous cell carcinoma
S Jiang, D Li, Z Liang, Y Wang… - … journal of biological …, 2020 - journals.sagepub.com
Background: Immunoglobulin binding protein 1 (IGBP1) is an important signal transduction
regulator that mediates various functions. However, its expression profile, role, and clinical …
regulator that mediates various functions. However, its expression profile, role, and clinical …