Movement of small RNAs in and between plants and fungi
RNA interference is a biological process whereby small RNAs inhibit gene expression
through neutralizing targeted mRNA molecules. This process is conserved in eukaryotes …
through neutralizing targeted mRNA molecules. This process is conserved in eukaryotes …
The evolutionary significance of RNAi in the fungal kingdom
C Lax, G Tahiri, JA Patiño-Medina… - International Journal of …, 2020 - mdpi.com
RNA interference (RNAi) was discovered at the end of last millennium, changing the way
scientists understood regulation of gene expression. Within the following two decades, a …
scientists understood regulation of gene expression. Within the following two decades, a …
[HTML][HTML] Evolutionary persistence of DNA methylation for millions of years after ancient loss of a de novo methyltransferase
S Catania, PA Dumesic, H Pimentel, A Nasif… - Cell, 2020 - cell.com
Cytosine methylation of DNA is a widespread modification of DNA that plays numerous
critical roles. In the yeast Cryptococcus neoformans, CG methylation occurs in transposon …
critical roles. In the yeast Cryptococcus neoformans, CG methylation occurs in transposon …
The interplay of phenotype and genotype in Cryptococcus neoformans disease
S Altamirano, KM Jackson, K Nielsen - Bioscience Reports, 2020 - portlandpress.com
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
meningitis primarily in immunocompromised individuals. In order to survive and proliferate …
meningitis primarily in immunocompromised individuals. In order to survive and proliferate …
Centromere scission drives chromosome shuffling and reproductive isolation
A fundamental characteristic of eukaryotic organisms is the generation of genetic variation
via sexual reproduction. Conversely, significant large-scale genome structure variations …
via sexual reproduction. Conversely, significant large-scale genome structure variations …
A non-canonical RNAi pathway controls virulence and genome stability in Mucorales
Epimutations in fungal pathogens are emerging as novel phenomena that could explain the
fast-developing resistance to antifungal drugs and other stresses. These epimutations are …
fast-developing resistance to antifungal drugs and other stresses. These epimutations are …
Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro
A Gusa, JD Williams, JE Cho… - Proceedings of the …, 2020 - National Acad Sciences
When transitioning from the environment, pathogenic microorganisms must adapt rapidly to
survive in hostile host conditions. This is especially true for environmental fungi that cause …
survive in hostile host conditions. This is especially true for environmental fungi that cause …
Diverse transposable element landscapes in pathogenic and nonpathogenic yeast models: the value of a comparative perspective
PH Maxwell - Mobile DNA, 2020 - Springer
Genomics and other large-scale analyses have drawn increasing attention to the potential
impacts of transposable elements (TEs) on their host genomes. However, it remains …
impacts of transposable elements (TEs) on their host genomes. However, it remains …
Pathogen and host genetics underpinning cryptococcal disease
Cryptococcosis is a severe fungal disease causing 220,000 cases of cryptococcal meningitis
yearly. The etiological agents of cryptococcosis are taxonomically grouped into at least two …
yearly. The etiological agents of cryptococcosis are taxonomically grouped into at least two …
Mating-Type-Specific Ribosomal Proteins Control Aspects of Sexual Reproduction in Cryptococcus neoformans
This study demonstrated that the ribosomal proteins Rpl22 and Rpl39 encoded by the MAT
locus of Cryptococcus neoformans are essential. Focusing on the RPL22a and RPL22α …
locus of Cryptococcus neoformans are essential. Focusing on the RPL22a and RPL22α …