Viral infection is controlled by host innate immune cells that express specialized receptors
for viral components. Engagement of these pattern recognition receptors triggers a series of …

In the last years, proteomics has represented a valuable approach to elucidate key aspects
in the regulation of type I/III interferons (IFNs) and autophagy, two main processes involved …

MAVS and MITA are essential adaptor proteins mediating innate antiviral immune
responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays …

The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in
various biological processes, especially in regulating a wide range of signaling pathways …

The diseases caused by viruses posed a great challenge to human health, the development
of which was driven by the imbalanced host immune response. Host innate immunity is an …

Ubiquitination is a prominent posttranslational modification, in which the ubiquitin moiety is
covalently attached to a target protein to influence protein stability, interaction partner and …

Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes,
and the enzymes involved are tightly regulated by multiple factors including posttranslational …

Innate immunity is an essential way for host cells to resist viral infection through the
production of interferons (IFNs) and proinflammatory cytokines. Interferon regulatory factor 3 …

Abstract IFN regulatory factor 3 (IRF3) is critical for the transcription of type I IFNs in
defensing virus and promoting inflammatory responses. Although several kinds of …

SAMHD 1 possesses multiple functions, but whether cellular factors regulate SAMHD 1
expression or its function remains not well characterized. Here, by investigating why cultured …