Microbial pathogens including Enterobacteriaceae family members bear different antibiotic
resistance genes comprising Extended-Spectrum-ß-Lactamases (ESBLs) and Metallo-ß …

A new member of the class metallo-β-lactamase (MBL), New Delhi metallo-beta-lactamase 1
(NDM-1) has emerged recently as a leading threat to the treatment of infections that have …

The distribution of fitness effects of mutation plays a central role in constraining protein
evolution. The underlying mechanisms by which mutations lead to fitness effects are …

Based on a structure-guided approach, aryl sulfonyl hydrazones conjugated with 1, 3-diaryl
pyrazoles were designed to target metallo-β-lactamases (MBLs), using Klebsiella …

At present, the resistance of New Delhi metallo-β-lactamase-1 (NDM-1) to carbapenems and
cephalosporins, one of the mechanisms of bacterial resistance against β-lactam antibiotics …

New Delhi metallo-β-lactamase-1 (NDM-1) has recently emerged as a global threat because
of its ability to confer resistance to all common β-lactam antibiotics. Understanding the …

The rise of Gram-negative pathogens expressing metallo-β-lactamases (MBLs) is a growing
concern, threatening the efficacy of β-lactam antibiotics, in particular, the carbapenems …

The fungal natural product aspergillomarasmine A (AMA) has been identified as a
noncompetitive inhibitor of New Delhi metallo‐β‐lactamase‐1 (NDM‐1) that inhibits by …

The bacteria, harboring metallo-β-lactamases (MβLs), become resistant on most β-lactam
antibiotics, specifically New Delhi metallo-β-lactamase-1 (NDM-1), which hydrolyzes almost …

New Delhi metallo-β-lactamase (NDM-1), one of the metallo-β-lactamases (MBLs), leads to
antibiotic resistance in clinical treatments due to the strong ability of hydrolysis to almost all …