Single-cell sequencing techniques from individual to multiomics analyses
Y Kashima, Y Sakamoto, K Kaneko, M Seki… - … & Molecular Medicine, 2020 - nature.com
Here, we review single-cell sequencing techniques for individual and multiomics profiling in
single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic …
single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic …
Integrative methods and practical challenges for single-cell multi-omics
Fast-developing single-cell multimodal omics (scMulti-omics) technologies enable the
measurement of multiple modalities, such as DNA methylation, chromatin accessibility, RNA …
measurement of multiple modalities, such as DNA methylation, chromatin accessibility, RNA …
Single-cell multimodal omics: the power of many
Advances in single-cell genomics technologies have enabled investigation of the gene
regulation programs of multicellular organisms at unprecedented resolution and scale …
regulation programs of multicellular organisms at unprecedented resolution and scale …
Multimodal single-cell chromatin analysis with Signac
The recent development of experimental methods for measuring chromatin state at single-
cell resolution has created a need for computational tools capable of analyzing these …
cell resolution has created a need for computational tools capable of analyzing these …
Cancer stem cell plasticity–a deadly deal
AP Thankamony, K Saxena, R Murali… - Frontiers in molecular …, 2020 - frontiersin.org
Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …
scAI: an unsupervised approach for the integrative analysis of parallel single-cell transcriptomic and epigenomic profiles
Simultaneous measurements of transcriptomic and epigenomic profiles in the same
individual cells provide an unprecedented opportunity to understand cell fates. However …
individual cells provide an unprecedented opportunity to understand cell fates. However …
[HTML][HTML] Single-cell ATAC sequencing analysis: from data preprocessing to hypothesis generation
S Baek, I Lee - Computational and structural biotechnology journal, 2020 - Elsevier
Most genetic variations associated with human complex traits are located in non-coding
genomic regions. Therefore, understanding the genotype-to-phenotype axis requires a …
genomic regions. Therefore, understanding the genotype-to-phenotype axis requires a …
Single-cell omics in ageing: a young and growing field
Organismal ageing results from interlinked molecular changes in multiple organs over time.
The study of ageing at the molecular level is complicated by varying decay characteristics …
The study of ageing at the molecular level is complicated by varying decay characteristics …
Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility
Joint profiling of transcriptome and chromatin accessibility within single cells allows for the
deconstruction of the complex relationship between transcriptional states and upstream …
deconstruction of the complex relationship between transcriptional states and upstream …
The impact of single-cell genomics on adipose tissue research
Adipose tissue is an important regulator of whole-body metabolism and energy
homeostasis. The unprecedented growth of obesity and metabolic disease worldwide has …
homeostasis. The unprecedented growth of obesity and metabolic disease worldwide has …