Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …

Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

The p53 transcription factor plays a critical role in cellular responses to stress. Its activation
in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs …

Cellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms,
contributes to tissue dysfunction, and drives age-related phenotypes. The clearance of …

Stem cells undergo dynamic changes in response to injury to regenerate lost cells.
However, the identity of transitional states and the mechanisms that drive their trajectories …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …

Cellular senescence is a key component of human aging that can be induced by a range of
stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

Cellular theory of aging states that human aging is the result of cellular aging, in which an
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …