The ability to replace defective cells in an airway with cells that can engraft, integrate, and
restore a functional epithelium could potentially cure a number of lung diseases. Progress …

Rationale: The respiratory tract constitutes an elaborate line of defense that is based on a
unique cellular ecosystem. Objectives: We aimed to investigate cell population distributions …

Background Clinical and epidemiologic studies have shown that obesity is associated with
asthma and that these associations differ by asthma subtype. Little is known about the …

Conjunctival goblet cells (CGCs) are specialized cells that produce and secrete soluble
mucins to the tear film that bathes the ocular surface. CGC numbers and functions are …

The type 2 cytokine-high asthma endotype (T2H) is characterized by IL-13-driven mucus
obstruction of the airways. To further investigate this incompletely understood pathobiology …

Viral-induced exacerbation of asthma remains a major cause of hospitalization and
mortality. New human-relevant models of the airways are urgently needed to understand …

Specific combinations of two transcription factors (Hnf4α plus Foxa1, Foxa2, or Foxa3) can
induce direct conversion of mouse fibroblasts into hepatocyte-like cells. However, the …

Patients who are prone to exacerbations of asthma experience significant costs in terms of
missed work and school, acute care visits, and hospitalizations. Exacerbations are largely …

Human rhinoviruses (HRVs) are associated with acute exacerbations in patients with
chronic obstructive pulmonary disease (COPD) and asthma, which are accompanied by …

Introduction: Evidence accumulated in the last decade has started to reveal the enormous
complexity in the expression, interactions and functions of the large number of different …