Immune cells of the myeloid and lymphoid lineages express Toll-like receptors (TLRs) to
recognize pathogenic components or cellular debris and activate the immune system …

Type I interferons (IFNs) are critical effector cytokines of the immune system and were
originally known for their important role in protecting against viral infections; however, they …

The application of adoptive T cell therapies, including those using chimeric antigen receptor
(CAR)-modified T cells, to solid tumors requires combinatorial strategies to overcome …

HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral
therapy (ART) because the virus persists in long-lived non-proliferating and proliferating …

The type I IFNs activate an array of signaling pathways, which are initiated after IFNs bind
their cognate receptors, IFNα/β receptor (IFNAR) 1 and IFNAR2. These signals contribute to …