[HTML][HTML] Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease

Y Li, J Zhang, J Wan, A Liu, J Sun - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

Link between diabetes and Alzheimer's disease due to the shared amyloid aggregation and deposition involving both neurodegenerative changes and neurovascular …

GD Stanciu, V Bild, DC Ababei, RN Rusu… - Journal of Clinical …, 2020 - mdpi.com
Diabetes and Alzheimer's disease are two highly prevalent diseases among the aging
population and have become major public health concerns in the 21st century, with a …

CHIP as a therapeutic target for neurological diseases

S Zhang, Z Hu, C Mao, C Shi, Y Xu - Cell death & disease, 2020 - nature.com
Carboxy-terminus of Hsc70-interacting protein (CHIP) functions both as a molecular co-
chaperone and ubiquitin E3 ligase playing a critical role in modulating the degradation of …

Amyloid beta hypothesis in Alzheimer's disease: major culprits and recent therapeutic strategies

D Vijayan, R Chandra - Current Drug Targets, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is one of the most common forms of dementia and has been a
global concern for several years. Due to the multi-factorial nature of the disease, AD has …

Exercise-mediated alteration of hippocampal Dicer mRNA and miRNAs is associated with lower BACE1 gene expression and Aβ1-42 in female 3xTg-AD mice

CM Dungan, T Valentino… - Journal of …, 2020 - journals.physiology.org
Changes to cerebral miRNA expression have been implicated in the progression of
Alzheimer's disease (AD), as miRNAs that regulate the expression of gene products …

[图书][B] Contribution of Intestinal Dysfunction to Alzheimer's Disease Progression

MS Thompson - 2020 - search.proquest.com
Longer life expectancies, due to advanced medical care, social, and environmental
conditions, helped increase the number and percentage of Americans aging to≥ 85. The …

Neuroinflammation in Alzheimer's Disease: a therapeutic target

S Zhu - 2020 - mspace.lib.umanitoba.ca
Abstract Alzheimer's disease (AD), the most common dementia, is an age-related
neurodegenerative disorder characterized by memory loss, extracellular β-amyloid (Aβ) …