[HTML][HTML] Zebrafish and medaka as models for biomedical research of bone diseases
L Lleras-Forero, C Winkler, S Schulte-Merker - Developmental biology, 2020 - Elsevier
The identification of disease-causing mutations has in recent years progressed immensely
due to whole genome sequencing approaches using patient material. The task accordingly …
due to whole genome sequencing approaches using patient material. The task accordingly …
Development of a straight vertebrate body axis
M Bagnat, RS Gray - Development, 2020 - journals.biologists.com
The vertebrate body plan is characterized by the presence of a segmented spine along its
main axis. Here, we examine the current understanding of how the axial tissues that are …
main axis. Here, we examine the current understanding of how the axial tissues that are …
Notochord vacuoles absorb compressive bone growth during zebrafish spine formation
J Bagwell, J Norman, K Ellis, B Peskin, J Hwang, X Ge… - Elife, 2020 - elifesciences.org
The vertebral column or spine assembles around the notochord rod which contains a core
made of large vacuolated cells. Each vacuolated cell possesses a single fluid-filled vacuole …
made of large vacuolated cells. Each vacuolated cell possesses a single fluid-filled vacuole …
Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway
X Sun, Y Zhou, R Zhang, Z Wang, M Xu… - Nature …, 2020 - nature.com
Congenital scoliosis (CS) is a complex genetic disorder characterized by vertebral
malformations. The precise etiology of CS is not fully defined. Here, we identify that mutation …
malformations. The precise etiology of CS is not fully defined. Here, we identify that mutation …
[HTML][HTML] Development and regeneration dynamics of the Medaka notochord
A Seleit, K Gross, J Onistschenko, M Woelk… - Developmental …, 2020 - Elsevier
The notochord is an embryonic tissue that acts as a hydrostatic skeleton until ossification
begins in vertebrates. It is composed of outer sheath cells and inner vacuolated cells, which …
begins in vertebrates. It is composed of outer sheath cells and inner vacuolated cells, which …
Serial blockface SEM suggests that stem cells may participate in adult notochord growth in an invertebrate chordate, the Bahamas lancelet
ND Holland, IML Somorjai - EvoDevo, 2020 - Springer
Background The cellular basis of adult growth in cephalochordates (lancelets or amphioxus)
has received little attention. Lancelets and their constituent organs grow slowly but …
has received little attention. Lancelets and their constituent organs grow slowly but …