Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain development
and function and are characterized by wide genetic and clinical variability. In this review, we …

Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

We present the largest exome sequencing study of autism spectrum disorder (ASD) to date
(n= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Recent success in identifying gene-regulatory elements in the context of recombinant adeno-
associated virus vectors has enabled cell-type-restricted gene expression. However, within …

INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

Autism spectrum disorder is a construct used to describe individuals with a specific
combination of impairments in social communication and repetitive behaviours, highly …

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a male-to-
female prevalence of 4: 1. However, the genetic mechanisms underlying this gender …

Autism spectrum disorder (ASD) is a largely heritable, multistage prenatal disorder that
impacts a child's ability to perceive and react to social information. Most ASD risk genes are …

Excitation-inhibition (E: I) imbalance is theorized as an important pathophysiological
mechanism in autism. Autism affects males more frequently than females and sex-related …

The promise of precision medicine lies in data diversity. More than the sheer size of
biomedical data, it is the layering of multiple data modalities, offering complementary …