Molecular networks in Network Medicine: Development and applications
EK Silverman, HHHW Schmidt… - … Systems Biology and …, 2020 - Wiley Online Library
Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …
pathogenesis. Many different analytical methods have been used to infer relevant molecular …
A psychometric network perspective on the validity and validation of personality trait questionnaires
AP Christensen, H Golino… - European Journal of …, 2020 - journals.sagepub.com
This article reviews the causal implications of latent variable and psychometric network
models for the validation of personality trait questionnaires. These models imply different …
models for the validation of personality trait questionnaires. These models imply different …
[HTML][HTML] Spatial transcriptomics and in situ sequencing to study Alzheimer's disease
Although complex inflammatory-like alterations are observed around the amyloid plaques of
Alzheimer's disease (AD), little is known about the molecular changes and cellular …
Alzheimer's disease (AD), little is known about the molecular changes and cellular …
A scalable SCENIC workflow for single-cell gene regulatory network analysis
B Van de Sande, C Flerin, K Davie, M De Waegeneer… - Nature protocols, 2020 - nature.com
This protocol explains how to perform a fast SCENIC analysis alongside standard best
practices steps on single-cell RNA-sequencing data using software containers and Nextflow …
practices steps on single-cell RNA-sequencing data using software containers and Nextflow …
[HTML][HTML] G3BP1 is a tunable switch that triggers phase separation to assemble stress granules
The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …
for establishing and maintaining RNP granules with distinct composition, are unknown. One …
Mass-spectrometry-based draft of the Arabidopsis proteome
Plants are essential for life and are extremely diverse organisms with unique molecular
capabilities. Here we present a quantitative atlas of the transcriptomes, proteomes and …
capabilities. Here we present a quantitative atlas of the transcriptomes, proteomes and …
[HTML][HTML] Deep multilayer brain proteomics identifies molecular networks in Alzheimer's disease progression
Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We
characterize AD stage-associated molecular networks by profiling 14,513 proteins and …
characterize AD stage-associated molecular networks by profiling 14,513 proteins and …
Cell type-specific transcriptomics reveals that mutant huntingtin leads to mitochondrial RNA release and neuronal innate immune activation
The mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in
Huntington's disease (HD) are not fully understood. To gain new molecular insights, we …
Huntington's disease (HD) are not fully understood. To gain new molecular insights, we …
Environmental DNA reveals seasonal shifts and potential interactions in a marine community
Environmental DNA (eDNA) analysis allows the simultaneous examination of organisms
across multiple trophic levels and domains of life, providing critical information about the …
across multiple trophic levels and domains of life, providing critical information about the …
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
Polygenic risk scores have identified that genetic variants without genome‐wide significance
still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how …
still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how …