Multisystem inflammatory syndrome in children (MIS-C), a post-viral myocarditis and systemic vasculitis—a critical review of its pathogenesis and treatment

JC McMurray, JW May, MW Cunningham… - Frontiers in …, 2020 - frontiersin.org
MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children
following COVID-19 infection. This review summarizes the literature on diagnosis …

Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

GU Meduri, D Annane, M Confalonieri… - Intensive care …, 2020 - Springer
Current literature addressing the pharmacological principles guiding glucocorticoid (GC)
administration in ARDS is scant. This paucity of information may have led to the …

Dexamethasone in hospitalised patients with COVID-19: addressing uncertainties

MA Matthay, BT Thompson - The Lancet Respiratory Medicine, 2020 - thelancet.com
The impressive results of the RECOVERY trial established that a moderate dose of
dexamethasone (6 mg daily for 10 days) reduced mortality in hospitalised patients with …

The current status of drug repositioning and vaccine developments for the COVID-19 pandemic

JH Won, H Lee - International Journal of Molecular Sciences, 2020 - mdpi.com
Since the outbreak of coronavirus disease 2019 (COVID-19) was first identified, the world
has vehemently worked to develop treatments and vaccines against severe acute …

Systematic review on the therapeutic options for COVID-19: clinical evidence of drug efficacy and implications

AR Abubakar, IH Sani, B Godman… - Infection and drug …, 2020 - Taylor & Francis
Abstract A novel coronavirus-2 (SARS-CoV-2) was first identified in Wuhan, China, and
quickly spread globally. Several treatments have been proposed, many of which have …

[HTML][HTML] The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19

YM Arabi, GP Chrousos, GU Meduri - Intensive care medicine, 2020 - Springer
The recent finding of the effectiveness of corticosteroid therapy in reducing mortality in
patients with severe coronavirus disease-19 (COVID-19) is a welcome breakthrough [1, 2, 3 …

Efficacy and safety of lopinavir/ritonavir for treatment of COVID-19: a systematic review and meta-analysis

S Alhumaid, A Al Mutair, Z Al Alawi, N Alhmeed… - Tropical medicine and …, 2020 - mdpi.com
(Background) Lopinavir-ritonavir (LPV/RTV) is a human immunodeficiency virus (HIV)
antiviral combination that has been considered for the treatment of COVID-19 disease.(Aim) …

Can natural polyphenols help in reducing cytokine storm in COVID-19 patients?

G Giovinazzo, C Gerardi, C Uberti-Foppa, L Lopalco - Molecules, 2020 - mdpi.com
SARS-CoV-2 first emerged in China during late 2019 and rapidly spread all over the world.
Alterations in the inflammatory cytokines pathway represent a strong signature during SARS …

Producing and using timely comparative evidence on drugs: lessons from clinical trials for covid-19

H Naci, AS Kesselheim, JA Røttingen, G Salanti… - bmj, 2020 - bmj.com
Producing and using timely comparative evidence on drugs: lessons from clinical trials for
covid-19 Page 1 Producing and using timely comparative evidence on drugs: lessons from …

[HTML][HTML] SARS‐CoV‐2 virus infection: targets and antiviral pharmacological strategies

DM de Oliveira Campos, UL Fulco… - Journal of evidence …, 2020 - ncbi.nlm.nih.gov
The current pandemic of coronavirus disease 2019 (COVID-19) poses a threat to global
public health owing to its high rate of spread and its association with severe forms of …