Effects of prenatal exposure to a mixture of organophosphate flame retardants on placental gene expression and serotonergic innervation in the fetal rat brain

KD Rock, G St Armour, B Horman… - Toxicological …, 2020 - academic.oup.com
There is a growing need to understand the potential neurotoxicity of organophosphate flame
retardants (OPFRs) and plasticizers because use and, consequently, human exposure, is …

DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling

N Bogush, L Tan, H Naib, E Faizullabhoy… - Scientific Reports, 2020 - nature.com
Cardiomyocytes of newborn mice proliferate after injury or exposure to growth factors.
However, these responses are diminished after postnatal day-6 (P6), representing a barrier …

Mediator subunit MED1 modulates intranuclear dynamics of the thyroid hormone receptor

MR Femia, RM Evans, J Zhang, X Sun… - Journal of cellular …, 2020 - Wiley Online Library
The thyroid hormone receptors (TRs) mediate thyroid hormone (T3)‐dependent gene
expression. The nuclear import and export signals that direct TR shuttling are well …

Characterization of TRα1 Mutants Associated with Metabolic Disorders and Cancer

C Lopez Silva - 2020 - scholarworks.wm.edu
The thyroid hormone receptor (TR) is a nuclear receptor that plays a critical role in human
development and metabolism, regulating thyroid hormone interactions. TR rapidly shuttles …