Aging is determined by complex interactions among genetic and environmental factors.
Increasing evidence suggests that the gut microbiome lies at the core of many age …

Fruit and vegetables (F&V) have been a cornerstone of healthy dietary recommendations;
the 2015–2020 US Dietary Guidelines for Americans recommend that F&V constitute one …

Dementia is one of the greatest global challenges for health and social care in the 21st
century. Alzheimer's disease (AD), the most common type of dementia, is by no means an …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

Frailty describes an individual's vulnerability to adverse health outcomes and is a useful
construct that assists health professionals to understand the heterogeneity of the ageing …

One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …

We propose in this review that hormesis, a concept profoundly and systematically addressed
by Mark Mattson, has to be considered a sort of comprehensive “contact point” capable of …

A central clinical question as the world deals with the COVID-19 pandemic is what the long-
term sequelae for the millions of individuals will be who recover from the hyperinflammatory …

During the course of evolution, bacteria have developed an intimate relationship with
humans colonizing specific body sites at the interface with the body exterior and …

Alterations in the immune system with aging are considered to underlie many age-related
diseases. However, many elderly individuals remain healthy until even a very advanced …