Context Acetylshikonin, a naphthoquinone derivative, is mainly extracted from some species
of the family Boraginaceae, such as Lithospermum erythrorhizon Sieb. et Zucc., Arnebia …

The genus Echium L. from the Boraginaceae family consists of 67 recognised species. The
genus is widely distributed in the Mediterranean, having been documented in the traditional …

Shikonin is a natural naphthoquinone compound and has demonstrated potent anti-cancer
activities; however, the underlying molecular mechanisms remained elusive. Here we report …

Colorectal carcinoma (CRC) is the third most common malignant tumor pathology
worldwide. Despite progress in surgical procedures and therapy options, CRC is still a …

Background Pancreatic ductal adenocarcinoma (PDAC) has poor survival and treatment
options. PDAC cells shift their metabolism towards glycolysis, which fuels the plasma …

Background/Aim: Pyruvate kinase M2 (PKM2) is an enzyme that is predominantly
overexpressed in various types of cancer. The role of PKM2 in liver fluke-associated …

Shikonin, shikonofuran and their derivatives are the main bioactive components of Zicao, a
traditional Chinese medicine prepared with the dried roots of Lithospermum erythrorhizon …

Profiling the chemical components of complicated herbal extracts using traditional analytical
methods is time-consuming and laborious. In this study, an integrated data filtering and …

Abstract Background Mast cells (MCs) are crucial effectors in allergic disorders by secreting
inflammatory mediators. The Mas-related G-protein-coupled receptor X2 (Mrgprx2) was …

Several Boraginaceae plants produce biologically active red naphthoquinone pigments,
derivatives of the enantiomers shikonin and alkannin, which vary in acyl groups on their side …