[HTML][HTML] An overview of Nrf2 signaling pathway and its role in inflammation

S Saha, B Buttari, E Panieri, E Profumo, L Saso - Molecules, 2020 - mdpi.com
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Treatment of multiple sclerosis: a review

SL Hauser, BAC Cree - The American journal of medicine, 2020 - Elsevier
Multiple sclerosis (MS) is an autoimmune demyelinating and neurodegenerative disease of
the central nervous system, and the leading cause of nontraumatic neurological disability in …

Myopia

PN Baird, SM Saw, C Lanca, JA Guggenheim… - Nature reviews Disease …, 2020 - nature.com
Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

[HTML][HTML] Oxidative stress-based therapeutics in COPD

PJ Barnes - Redox biology, 2020 - Elsevier
Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …

[HTML][HTML] Targeting immunometabolism as an anti-inflammatory strategy

EM Pålsson-McDermott, LAJ O'Neill - Cell research, 2020 - nature.com
The growing field of immunometabolism has taught us how metabolic cellular reactions and
processes not only provide a means to generate ATP and biosynthetic precursors, but are …

Exploring uncertainty measures in deep networks for multiple sclerosis lesion detection and segmentation

T Nair, D Precup, DL Arnold, T Arbel - Medical image analysis, 2020 - Elsevier
Deep learning networks have recently been shown to outperform other segmentation
methods on various public, medical-image challenge datasets, particularly on metrics …

NRF2 as a therapeutic target in neurodegenerative diseases

MS Brandes, NE Gray - ASN neuro, 2020 - journals.sagepub.com
Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

The apparently milder course of multiple sclerosis: changes in the diagnostic criteria, therapy and natural history

PS Sorensen, F Sellebjerg, HP Hartung, X Montalban… - Brain, 2020 - academic.oup.com
In the past decade, changes have occurred in the spectrum of multiple sclerosis courses.
The natural history of multiple sclerosis appears milder from the first sign of demyelinating …

Transcription factor NRF2 as a promising therapeutic target for Alzheimer's disease

Z Qu, J Sun, W Zhang, J Yu, C Zhuang - Free Radical Biology and …, 2020 - Elsevier
Oxidative stress is considered as one of the pathogenesis of Alzheimer's disease (AD) and
plays an important role in the occurrence and development of AD. Nuclear factor erythroid 2 …

[HTML][HTML] Antioxidant and anti-inflammatory effect of Nrf2 inducer dimethyl fumarate in neurodegenerative diseases

SA Scuderi, A Ardizzone, I Paterniti, E Esposito… - Antioxidants, 2020 - mdpi.com
Neurodegenerative diseases (NDs) represents debilitating conditions characterized by
degeneration of neuronal cells in specific brain areas, causing disability and death in …