Long-term outcomes in systemic lupus erythematosus: trends over time and major contributors

L Arnaud, MG Tektonidou - Rheumatology, 2020 - academic.oup.com
SLE is a chronic autoimmune rheumatic disorder of high heterogeneity in clinical
presentation, treatment response and prognosis. Long-term outcomes in SLE have been …

The effect of hydroxychloroquine on thrombosis prevention and antiphospholipid antibody levels in primary antiphospholipid syndrome: a pilot open label randomized …

E Kravvariti, A Koutsogianni, E Samoli, PP Sfikakis… - Autoimmunity …, 2020 - Elsevier
Background Sporadic studies suggest hydroxychloroquine (HCQ) may be effective for
thrombosis prevention in patients with primary antiphospholipid syndrome (PAPS) and may …

Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS

S Chaturvedi, EM Braunstein, X Yuan… - Blood, The Journal …, 2020 - ashpublications.org
The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy
morbidity in the presence of antiphospholipid antibodies, including anti-β2-glycoprotein-I …

Complementopathies and precision medicine

E Gavriilaki, RA Brodsky - The Journal of clinical …, 2020 - Am Soc Clin Investig
The renaissance of complement diagnostics and therapeutics has introduced precision
medicine into a widened field of complement-mediated diseases. In particular, complement …

Thrombocytopenia in pregnancy: Diagnosis and approach to management

AM Pishko, LD Levine, DB Cines - Blood reviews, 2020 - Elsevier
Thrombocytopenia during pregnancy presents unique challenges for the hematologist.
Obstetricians generally manage many of the pregnancy-specific etiologies, ranging from the …

An update on the management of antiphospholipid syndrome

M Rodziewicz, DP D'Cruz - Therapeutic Advances in …, 2020 - journals.sagepub.com
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by
recurrent venous or arterial thrombosis with or without pregnancy morbidity in the presence …

[HTML][HTML] Pediatric antiphospholipid syndrome

JA Madison, Y Zuo, JS Knight - European Journal of Rheumatology, 2020 - ncbi.nlm.nih.gov
Despite its potential to cause significant morbidity in children, pediatric antiphospholipid
syndrome (APS) is an understudied condition. In this review, we will cover what is known …

The antiphospholipid syndrome–often overlooked cause of vascular occlusions?

E Svenungsson, A Antovic - Journal of Internal Medicine, 2020 - Wiley Online Library
The antiphospholipid syndrome (APS) was fully recognized as a clinical entity in the early
1980s. Still, more than 30 years later, the epidemiology of APS is not well described, and …

Management of non-criteria manifestations in antiphospholipid syndrome

E Xourgia, MG Tektonidou - Current Rheumatology Reports, 2020 - Springer
Abstract Purpose of the Review To review the available evidence on the management of a
variety of non-criteria manifestations in antiphospholipid syndrome (APS), including valvular …

Childhood-onset systemic lupus erythematosus-related antiphospholipid syndrome: a multicenter study with 1519 patients

AG Islabão, LMH Mota, MCM Ribeiro, TM Arabi… - Autoimmunity …, 2020 - Elsevier
Objective To assess childhood-onset systemic lupus erythematosus-related
antiphospholipid syndrome (cSLE-APS) in a large Brazilian population. Methods A …