[HTML][HTML] Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery

T Malachowski, A Hassel - Engineered Regeneration, 2020 - Elsevier
Nanotechnology has recently gained traction in the medical field as a method of targeted
delivery and timed release of therapeutic drugs. As interest in this field grows, design …

Genotoxicity of nanomaterials: Advanced in vitro models and high throughput methods for human hazard assessment—A review

Y Kohl, E Rundén-Pran, E Mariussen, M Hesler… - Nanomaterials, 2020 - mdpi.com
Changes in the genetic material can lead to serious human health defects, as mutations in
somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic …

Chitosan nanoparticles: shedding light on immunotoxicity and hemocompatibility

S Jesus, AP Marques, A Duarte, E Soares… - … in bioengineering and …, 2020 - frontiersin.org
Nanoparticles (NPs) assumed an important role in the area of drug delivery. Despite the
number of studies including NPs are growing over the last years, their side effects on the …

Intracellular antioxidant activity of biocompatible citrate-capped palladium nanozymes

M Moglianetti, D Pedone, G Udayan, SF Retta… - Nanomaterials, 2020 - mdpi.com
A method for the aqueous synthesis of stable and biocompatible citrate-coated palladium
nanoparticles (PdNPs) in the size range comparable to natural enzymes (4–8 nm) has been …

Interference: a much-neglected aspect in high-throughput screening of nanoparticles

C Andraos, IJ Yu, M Gulumian - International journal of …, 2020 - journals.sagepub.com
Despite several studies addressing nanoparticle (NP) interference with conventional toxicity
assay systems, it appears that researchers still rely heavily on these assays, particularly for …

When would immunologists consider a nanomaterial to be safe? Recommendations for planning studies on nanosafety

M Himly, M Geppert, S Hofer, N Hofstätter… - Small, 2020 - Wiley Online Library
The immune system is professional in recognizing and responding to non‐self, including
nanomaterials. Immune responses by professional and nonprofessional immune cells are …

How to address the adjuvant effects of nanoparticles on the immune system

A Feray, N Szely, E Guillet, M Hullo, FX Legrand… - Nanomaterials, 2020 - mdpi.com
As the nanotechnology market expands and the prevalence of allergic diseases keeps
increasing, the knowledge gap on the capacity of nanomaterials to cause or exacerbate …

Biological effects of allergen–nanoparticle conjugates: uptake and immune effects determined on hAELVi cells under submerged vs. air–liquid interface conditions

R Mills-Goodlet, M Schenck, A Chary… - Environmental …, 2020 - pubs.rsc.org
Type I hypersensitivity reactions against environmental entities, ie allergens, are an ever
growing problem, with increasing numbers of affected individuals in Western countries. In …

In vivo immunotoxicity of Gd2O3:Eu3+ nanoparticles and the associated molecular mechanism

C Zheng, X Tian, J Cai, L Huang… - … of Biochemical and …, 2020 - Wiley Online Library
The in vivo toxicity of Gd2O3: Eu3+ nanoparticles (NPs) used as dual‐modal nanoprobes for
molecular imaging has not been studied, and the corresponding molecular mechanism of …

[HTML][HTML] Evaluation of in vivo immunotoxicity for Ho3+-doped Gd2O3 nanoparticles as dual-modality nanoprobes

X Tian, Z Liu, A Zeng, H Wang, J Lou, Y Wei… - Materials Today …, 2020 - Elsevier
Rare-earth-doped gadolinium-oxide (Gd 2 O 3) nanoparticles (NPs) are increasingly used
for magnetic resonance imaging (MRI) and optical imaging (OI). However, to date, the poor …