The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

Multiple surgical targets for treating obsessive-compulsive disorder with deep brain
stimulation (DBS) have been proposed. However, different targets may modulate the same …

Deep brain stimulation is an established therapy for multiple brain disorders, with rapidly
expanding potential indications. Neuroimaging has advanced the field of deep brain …

Abstract Deep Brain Stimulation (DBS) is an established treatment option for movement
disorders and is under investigation for treatment in a growing number of other brain …

Subthalamic deep brain stimulation (STN-DBS) for Parkinson's disease treats motor
symptoms and improves quality of life, but can be complicated by adverse neuropsychiatric …

Dopamine and striatal dysfunctions play a key role in the pathophysiology of Parkinson's
disease (PD) and Dystonia, but our understanding of the changes in the discharge rate and …

Subplate neurons (SpNs) are one of the earliest born and matured neurons in the
developing cerebral cortex and play an important role in the early development of the …

Background The Papez circuit was first described as the anatomic basis of emotion.
Subsequent studies consolidated recognition of its limbic activities but showed a more …

The brainstem, a structure of vital importance in mammals, is currently becoming a principal
focus in cognitive, affective, and clinical neuroscience. Midbrain, pontine and medullary …

Objective Phasic bursts of beta band synchronisation have been linked to motor impairment
in Parkinson's disease (PD). However, little is known about what terminates bursts. Methods …