Measuring biological aging in humans: A quest
L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …
[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases
Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …
alterations in aging and age-related disease. It is currently well established that DNA …
[HTML][HTML] Why does COVID-19 disproportionately affect older people?
AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
Personal aging markers and ageotypes revealed by deep longitudinal profiling
The molecular changes that occur with aging are not well understood,,–. Here, we
performed longitudinal and deep multiomics profiling of 106 healthy individuals from 29 to …
performed longitudinal and deep multiomics profiling of 106 healthy individuals from 29 to …
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up
Biological age measurements (BAs) assess aging-related physiological change and predict
health risks among individuals of the same chronological age (CA). Multiple BAs have been …
health risks among individuals of the same chronological age (CA). Multiple BAs have been …
[HTML][HTML] What is new in the exposome?
P Vineis, O Robinson, M Chadeau-Hyam… - Environment …, 2020 - Elsevier
The exposome concept refers to the totality of exposures from a variety of external and
internal sources including chemical agents, biological agents, or radiation, from conception …
internal sources including chemical agents, biological agents, or radiation, from conception …
Plasma proteomic biomarker signature of age predicts health and life span
Older age is a strong shared risk factor for many chronic diseases, and there is increasing
interest in identifying aging biomarkers. Here, a proteomic analysis of 1301 plasma proteins …
interest in identifying aging biomarkers. Here, a proteomic analysis of 1301 plasma proteins …
DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan
T Bergsma, E Rogaeva - Neuroscience insights, 2020 - journals.sagepub.com
The number of age predictors based on DNA methylation (DNAm) profile is rising due to
their potential in predicting healthspan and application in age-related illnesses, such as …
their potential in predicting healthspan and application in age-related illnesses, such as …
[HTML][HTML] Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities
The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
Background Individuals of the same chronological age display different rates of biological
ageing. A number of measures of biological age have been proposed which harness age …
ageing. A number of measures of biological age have been proposed which harness age …