Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …

Learning valence-based responses to favorable and unfavorable options requires
judgments of the relative value of the options, a process necessary for species survival. We …

Huntington disease (HD) is a devastating neurodegenerative disorder caused by a CAG
repeat expansion in the huntingtin gene. Disrupted cortico-striatal transmission is an early …

GPR52 is an orphan G protein-coupled receptor (GPCR) that has been recently implicated
as a potential drug target of Huntington's disease (HD), an incurable monogenic …

In the BACHD mouse model of Huntington's disease (HD), deletion of the N17 domain of the
Huntingtin gene (BACHDΔN17, Q97) has been reported to lead to nuclear accumulation of …

Production of learned vocalizations requires precise selection and accurate sequencing of
appropriate vocal-motor actions. The basal ganglia are essential for the selection and …

Uncovering the mechanisms that drive cell type-specific vulnerability differences in
Huntington's disease (HD) is an imperative prerequisite to finding a reliable therapeutic …