Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Pluripotent stem cells (PSCs) are capable of unlimited self-renewal in culture and
differentiation into all functional cell types in the body, and thus hold great promise for …

Palmitic acid (PA), the main component of dietary saturated fat, has been known to increase
in patients with obesity, and PA‐induced lipotoxicity may contribute to obesity‐related male …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …

As a plant hormone, salicylic acid (SA) plays essential roles in plant defense against
biotrophic and hemibiotrophic pathogens. Significant progress has been made in …

Background Heart failure (HF) is an epidemic disease with increased incidence annually. It
has been reported that taurine can improve cardiac function. This study investigated the …

Colorectal cancer (CRC) is one of the most frequently diagnosed tumor in humans and one
of the most common causes of cancer-related death worldwide. The pathogenesis of CRC …

p53 is a well-known tumor suppressor gene and one of the most extensively studied genes
in cancer research. p53 functions largely as a transcription factor and can trigger a variety of …

Mycoplasmas are the smallest free-living organisms. Reduced sizes of their genomes put
constraints on the ability of these bacteria to live autonomously and make them highly …

Abstract p53 is a key transcription factor to regulate gene transcription. However, the
molecular mechanism of chromatin-associated p53 on gene transcription remains elusive …