[HTML][HTML] Polygenic risk and pleiotropy in neurodegenerative diseases

E Bellou, J Stevenson-Hoare, V Escott-Price - Neurobiology of Disease, 2020 - Elsevier
In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases,
focusing on Alzheimer's disease (AD). We summarize the various techniques developed to …

Retinal microvascular attenuation in mental cognitive impairment and Alzheimer's disease by optical coherence tomography angiography

J Wu, X Zhang, G Azhati, T Li, G Xu… - Acta …, 2020 - Wiley Online Library
Purpose To explore regional variation of the macular microvasculature in patients with mild
cognitive impairment (MCI) and Alzheimer's disease (AD), also to detect the association …

Genetic variants behind cardiovascular diseases and dementia

WM Ho, YY Wu, YC Chen - Genes, 2020 - mdpi.com
Cardiovascular diseases (CVDs) and dementia are the leading causes of disability and
mortality. Genetic connections between cardiovascular risk factors and dementia have not …

Natural selection at the NHLH2 core promoter exceptionally long CA-repeat in human and disease-only genotypes in late-onset neurocognitive disorder

H Afshar, F Adelirad, A Kowsari, N Kalhor, A Delbari… - Gerontology, 2020 - karger.com
Background: Approximately 2% of the human core promoter short tandem repeats (STRs)
reach lengths of≥ 6 repeats, which may in part be a result of adaptive evolutionary …

Evolving evidence on a link between the ZMYM3 exceptionally long GA-STR and human cognition

H Afshar, S Khamse, F Alizadeh, A Delbari… - Scientific reports, 2020 - nature.com
The human X-linked zinc finger MYM-type protein 3 (ZMYM3) contains the longest GA-STR
identified across protein-coding gene 5′ UTR sequences, at 32-repeats. This exceptionally …

Ca: Mg ratio, APOE cytosine modifications, and cognitive function: results from a randomized trial

X Zhu, AR Borenstein, Y Zheng… - Journal of …, 2020 - content.iospress.com
Background: Deterioration of ionized calcium (Ca2+) handling in neurons could lead to
neurodegenerative disease. Magnesium (Mg) antagonizes Ca during many physiologic …

Effect of Experimental Ischemic Stroke and PGE 2 EP1 Selective Antagonism in Alzheimer's Disease Mouse Models

FR Mendes, JL Leclerc, L Liu, PK Kamat… - Journal of …, 2020 - content.iospress.com
Background: Neuroinflammation has been recognized as an important factor in the
pathogenesis of Alzheimer's disease (AD). One of the most recognized pathways in …

Systemic inflammation causes microglial dysfunction with a mixed AD-like pathology

P Bathini, I Dupanloup, E Zenaro, E Terrabuio… - bioRxiv, 2020 - biorxiv.org
Background Alzheimer's disease (AD) is the primary cause of cognitive deficit in elderly
humans. Late-onset AD (LOAD) is sporadic, multifactorial, non-Mendelian accounting at …

[PDF][PDF] Investigating genetic, microbial-viral, and other environmental factors in neuroinflammatory and neurodegenerative diseases of CNS through '-omics' or 'meta …

ΑΦ Μεντής - 2020 - ir.lib.uth.gr
My native place, Greece, has long suffered a tough and unrelenting period of austerity. Why
return to my native place beaten by the financial crisis to pursue my biomedical PhD studies …