The role of biomarkers in acute kidney injury

N Srisawat, JA Kellum - Critical care clinics, 2020 - criticalcare.theclinics.com
In the past 50 years, the diagnosis of acute kidney injury (AKI) has been mainly based on
serum creatinine. 1 It is well known that an increase in serum creatinine level occurs after a …

Neutrophil gelatinase-associated lipocalin measured on clinical laboratory platforms for the prediction of acute kidney injury and the associated need for dialysis …

C Albert, A Zapf, M Haase, C Röver… - American Journal of …, 2020 - Elsevier
Rationale & Objective The usefulness of measures of neutrophil gelatinase-associated
lipocalin (NGAL) in urine or plasma obtained on clinical laboratory platforms for predicting …

[HTML][HTML] Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

M Ostermann, R Bellomo, EA Burdmann, K Doi… - Kidney international, 2020 - Elsevier
In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the
classification and management of acute kidney injury (AKI). The guideline was derived from …

Acute kidney injury in SARS-CoV-2 infected patients

V Fanelli, M Fiorentino, V Cantaluppi, L Gesualdo… - Critical Care, 2020 - Springer
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the
pathogen responsible of atypical pneumonia that has affected more than 330,000 people …

[HTML][HTML] Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis

Z Liu, D Yang, J Gao, X Xiang, X Hu, S Li, W Wu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Sepsis is the cause of nearly half of acute kidney injury (AKI) and, unfortunately,
AKI in sepsis is associated with unacceptably high rates of mortality. Early detection of AKI …

A long journey for acute kidney injury biomarkers

DJ Oh - Renal failure, 2020 - Taylor & Francis
Acute kidney injury (AKI) is a life-threatening illness that continues to have an in-hospital
mortality rate of patients with AKI ranges from 20% to 50% or greater, depending on …

Potential targeted therapy and diagnosis based on novel insight into growth factors, receptors, and downstream effectors in acute kidney injury and acute kidney injury …

LI Gao, X Zhong, J Jin, J Li, X Meng - Signal transduction and targeted …, 2020 - nature.com
Acute kidney injury (AKI) is defined as a rapid decline in renal function and is characterized
by excessive renal inflammation and programmed death of resident cells. AKI shows high …

Acute kidney injury and urinary biomarkers in hospitalized patients with coronavirus disease-2019

F Husain-Syed, J Wilhelm, S Kassoumeh… - Nephrology Dialysis …, 2020 - academic.oup.com
The outbreak of coronavirus disease 2019 (COVID-19) has rapidly evolved into a global
pandemic. Acute kidney injury (AKI) is common among critically ill patients with COVID-19 …

Serial measurement of cell-cycle arrest biomarkers [TIMP-2]·[IGFBP7] and risk for progression to death, dialysis, or severe acute kidney injury in patients with septic …

M Fiorentino, Z Xu, A Smith, K Singbartl… - American journal of …, 2020 - atsjournals.org
Rationale: Urinary TIMP-2 (tissue inhibitor of metalloproteinases-2) and IGFBP7 (insulin-like
growth factor–binding protein 7) can predict acute kidney injury (AKI) in patients with sepsis …

Nephrotoxicity of herbal medicine and its prevention

X Xu, R Zhu, J Ying, M Zhao, X Wu, G Cao… - Frontiers in …, 2020 - frontiersin.org
Herbal medicine (HM) has been widely used to treat diseases for thousands of years and
has greatly contributed to the health of human beings. Many new drugs have been …