Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines

B Kirk, J Feehan, G Lombardi, G Duque - Current osteoporosis reports, 2020 - Springer
Abstract Purpose of Review Skeletal muscle and bone are connected anatomically and
physiologically, and play a crucial role in human locomotion and metabolism. Historically …

A clinical guide to the pathophysiology, diagnosis and treatment of osteosarcopenia

B Kirk, S Miller, J Zanker, G Duque - Maturitas, 2020 - Elsevier
Advances in medicine have paved the way for older persons to live longer, but with more
years spent living with disability and dependency. Many older persons are living with …

Bimagrumab vs optimized standard of care for treatment of sarcopenia in community-dwelling older adults: a randomized clinical trial

D Rooks, T Swan, B Goswami, LA Filosa… - JAMA network …, 2020 - jamanetwork.com
Importance The potential benefit of novel skeletal muscle anabolic agents to improve
physical function in people with sarcopenia and other muscle wasting diseases is unknown …

Associations between osteoporosis, the severity of sarcopenia and fragility fractures in community-dwelling older adults

B Kirk, S Phu, SL Brennan-Olsen… - European geriatric …, 2020 - Springer
Purpose To investigate the association between bone mineral density (BMD) and the
severity of sarcopenia using the revised European Working Group on Sarcopenia in Older …

Growth differentiation factor-15 as a biomarker for sarcopenia in aging humans and mice

H Kim, KM Kim, MJ Kang, S Lim - Experimental Gerontology, 2020 - Elsevier
Sarcopenia is a pathologic status characterized by impaired muscle strength or function
accompanying decreased muscle mass. It results in increased vulnerability to chronic …

AChRs degeneration at NMJ in aging-associated sarcopenia–a systematic review

Z Bao, C Cui, SKH Chow, L Qin, RMY Wong… - Frontiers in Aging …, 2020 - frontiersin.org
Sarcopenia is an aging process with a decline of skeletal muscle mass and function, which
is a challenging public health problem with reduced quality of life in patients. The endplate …

Updated concept of sarcopenia based on muscle–bone relationship

M Yakabe, T Hosoi, M Akishita, S Ogawa - Journal of bone and mineral …, 2020 - Springer
Sarcopenia is an age-related loss of skeletal muscle mass and strength. It has been widely
recognized that low muscle mass was essential in the diagnosis of sarcopenia, whereas …

[HTML][HTML] The effectiveness of exercises on fall and fracture prevention amongst community elderlies: A systematic review and meta-analysis

RMY Wong, KC Chong, SW Law, WT Ho, J Li… - Journal of orthopaedic …, 2020 - Elsevier
Objective To analyze the effectiveness of exercise interventions on falls and fall-related
fracture prevention among community-dwelling elderlies. Methods Literature search was …

Loss in DXA-estimated total body lean mass but not fat mass predicts incident major osteoporotic fracture and hip fracture independently from FRAX: a registry-based …

WD Leslie, JT Schousboe, SN Morin, P Martineau… - Archives of …, 2020 - Springer
Abstract Summary During median follow-up 6.0 years in 9622 individuals, prior loss in
estimated total body lean mass (TBLM), but not total body fat mass loss (TBFM), was …

Is a healthy diet also suitable for the prevention of fragility Fractures?

E Warensjö Lemming, L Byberg - Nutrients, 2020 - mdpi.com
Osteoporosis and sarcopenia contribute to the risk of fracture in the population. These
conditions share common features, and it is known that a healthy diet may have beneficial …